Why do some people feel refreshed after drinking coffee, while others feel anxious and can't sleep? It has something to do with this

Why do some people feel refreshed, energetic, active in thinking, and feel like they can work for 24 hours after drinking coffee, while others experience adverse reactions such as stomach discomfort, palpitations, increased blood pressure, and insomnia after drinking coffee?

Let’s first look at the advantages and disadvantages of drinking coffee.

Research results from the American Coffee Research Institute show that coffee contains four times more anti-dementia substances (including vitamin E, vitamin C, carotene, etc.) than tea. Roasted coffee beans are more effective in fighting dementia, and the effect of decaffeinated coffee will not be weakened or destroyed.

Three cups of coffee a day can prevent gallstones. Caffeinated coffee can stimulate the contraction of the gallbladder and reduce the cholesterol in the bile that is prone to forming gallstones. Researchers at Harvard University in the United States found that men who drink two to three cups of coffee a day have a 40% lower chance of getting gallstones.

However, no matter how good the coffee is, you can’t drink too much!

1. Drinking coffee can only boost your spirits in the short term, but long-term excessive consumption will accelerate brain aging.

About 85% of Americans admit to drinking coffee every day. Coffee temporarily increases your heart rate and blood pressure, making you feel refreshed and focused. However, Dr. Theresa Aubrey, a neuroscience research expert at Florida State University, believes that drinking too much coffee can make people nervous and tense, dehydrate brain tissue, reduce blood supply, and accelerate the aging process of the brain.

2. Caffeine can only improve mechanical work efficiency, but will not enhance creative thinking.

You may think that coffee can refresh your mind, make you smarter, and greatly improve your work efficiency. Is this really the case? Studies have found that the caffeine contained in coffee can only improve the efficiency of those jobs that do not require fine thinking or abstract thinking. Caffeine seems to slightly speed up your thinking speed and enhance your mechanical memory ability, but it will not enhance your creative thinking. Moreover, the human body will gradually tolerate caffeine, and you have to take more and more caffeine to produce the same refreshing effect.

3. Drinking more than 5 cups of coffee increases the risk of auditory hallucinations, and can also cause headaches and anxiety .

An Australian study says drinking just five cups of coffee may increase your risk of hearing or seeing hallucinations. A 2009 study found that drinking three cups of coffee tripled the likelihood of hearing or seeing hallucinations. Note that caffeine is not only found in coffee beans, but also in tea leaves, cocoa beans, and processed products derived from these raw materials, as well as in a variety of medicines, such as painkillers, diuretics, and vitamin supplements. Studies have found that caffeine can increase the level of hydrocortisone in your body, making you feel more nervous. Consuming large amounts of caffeine can also irritate your gastrointestinal tract, cause headaches, cause anxiety, and act as a diuretic, preventing you from getting a good night's sleep.

4. Do not consume more than 417 mg of caffeine per day, otherwise it will cause arrhythmia.

In pharmacology, Aubrey recommends not to consume more than 417 mg of caffeine per day. Doctors have found that consuming 600 mg of caffeine per day can cause anxiety, breathing difficulties and even arrhythmia - this intake is roughly equivalent to drinking a liter of freshly ground coffee from coffee beans. Caffeine begins to make people feel it 10 to 15 minutes after it is ingested, and the effect can last for 2 to 3 hours. People who are accustomed to consuming 300 mg of caffeine per day will experience withdrawal symptoms after suddenly stopping intake, including fatigue, depression, irritability, tremors, and headaches.

Now let’s look at the question at the beginning: why some people feel energetic and their sleep is not affected after drinking coffee, while others can’t stand even one cup.

This is related to the genes of our body.

This is related to the differences in genes of each person. A gene called CYP1A2 controls the rate at which caffeine is metabolized in the body. This gene has two types: fast and slow.

Caffeine is metabolized by the liver's CYP450 enzyme (Cytochrome P450). People with fast caffeine metabolizing enzymes (containing *1A/*1A genes) are not sensitive to caffeine, and the coffee they drink is metabolized quickly, so the panic symptoms are mild and they are more tolerant. However, people with slow caffeine metabolization (containing *1A/*1F+*1F/*1F genes) are very sensitive to caffeine and cannot metabolize it. They will feel panic and unable to sleep after drinking a little coffee.

In the study of the caffeine genome in hypertension, it was found that if hypertensive patients have fast metabolism genes (*1A/*1A), drinking 4 cups of coffee a day will reduce the risk of hypertension compared to drinking 1-3 cups of coffee. On the contrary, hypertensive patients with slow metabolism genes (*1A/*1F+*1F/*1F) have a greater risk the more coffee they drink, including the risk of myocardial infarction. Coffee itself is a phytonutrient that is good for heart health. Caffeine can help unclog blood vessels and has a mild sodium excretion effect. For hypertensive and diabetic patients with fast metabolism, drinking 1-3 cups of coffee a day can reduce the risk of hypertension, diabetes and cardiovascular disease, while it may increase the risk for slow metabolism.

How do you know if you have a fast or slow metabolizer?

Drink a normal cup of coffee (about 200-250ml) and if you don't feel a headache, palpitations, anxiety or stomach discomfort within an hour, then you are a fast metabolizer and will probably benefit from coffee. On the contrary, if you experience any of the above, it is recommended that you drink less coffee in the future.

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