Why do some people suffer from insomnia after drinking coffee, while others are fine?

Many people think about caffeine when they drink coffee. The Mayo Clinic in the United States reports that it is completely safe for healthy adults to consume 400 mg of caffeine a day.

So the question is, how much does the coffee we usually drink contain?

According to a report by TechInsider, a website dedicated to reporting real science and technology news and information~

We've found the caffeine stats you're most interested in:

A 12-ounce cup of American coffee: McDonald's = 109 mg, Starbucks = 260 mg

A 12-ounce cup of latte, McDonald's = 71mg, Starbucks = 75mg

1 ounce of espresso contains 45-75 mg, and hand-brewed coffee contains 20 mg

Then the question arises again, why!

Why can't you fall asleep after drinking a sip of coffee, but he can drink no matter how much he drinks?

A British research team analyzed the genomes of two Italian populations and found a gene that may be related to coffee consumption. The researchers believe that this gene may regulate the expression of genes related to caffeine metabolism. The relevant paper was published on the website of the journal Scientific Reports.

Caffeine is an alkaloid compound and a central nervous system stimulant that can block sleepiness, excite the mind and increase vitality in a short period of time. However, the reaction is different in different people. For example, some people are extremely sensitive to coffee and can take effect after drinking a small amount, while others feel that it is no different from plain water.

To clarify this issue, Nicola Pilastou and his research team at the University of Edinburgh in the UK conducted a genome-wide association analysis in two Italian populations.

One group consisted of 370 people from a small village in southern Italy; the other group consisted of 843 people from six villages in northeastern Italy.

For the study, researchers asked participants from Italy about their daily coffee consumption and repeated the experiment on 1,731 independent participants from the Netherlands.

They found that the expression of a gene called PDSS2 was negatively correlated with coffee consumption. If the protein level of the PDSS2 gene was high, the expression of genes related to the caffeine metabolism pathway would be inhibited, thereby hindering the degradation of caffeine.

The researchers said the new study identified the PDSS2 gene and linked it to coffee consumption, but further research and a larger number of subjects are needed to confirm the results.

On average, caffeine can last for about 3 to 4 hours in the body. However, some people have poorer metabolism, and the effect may last for 8 to 12 hours. Therefore, for people who metabolize caffeine slowly, the following suggestions are for you:

1) Don’t drink coffee after dinner if you’re worried about not being able to sleep

2) Drink less instant and cheap coffee beans

3) The longer the extraction time, the more time the coffee particles are in contact with the hot water, and the more caffeine is extracted

4) Iced coffee has less caffeine than hot coffee

[Taobao.com] Coffee beans Italian espresso premium sugar-free concentrated blended black coffee powder can be ground freshly 1kg*2 bulk pack Taobao password: $rEH31VE2B7P$ | Click here to copy the Italian espresso premium coffee beans coupon, the price is 59.9 yuan to get a 20 yuan coupon